Walk This Way to Live Longer (Backed by New Science)

Even under 8k steps might still have notable benefits.  It is convenient to walk more than 15 minutes at a time to reduce all cause mortality.

Dr. Sinclair's Protocol Updates In 2025

Comment

I take taurine, nmn, pqq, ergothioneine, urolithin a, spirulina, omega 3, magnesium, vitd+k2, hydroxytyrosol. Recently started taking nugevia resveratrol, which is best taken on a fasted empty stomach, iirc. Nugevia uses micellar resveratrol which is being tested as a resveratrol drug called Jotrol. 500mg Jotrol is said can exceed blood levels of 5g micronized resveratrol, nearly doubling them, that is it approaches levels that would take nearly 10g of expensive micronized resveratrol.

10g micronized is not just expensive but overloads system with metabolic byproducts, Jotrol can achieve the benefits of this at far lower dose without the side effects or issues of such high dose micronized.

In lemur primates, it was seen that high dose resveratrol was able to extend median lifespan over 20 percent, albeit too few primates were used to reach statistical significance in the study, and thus it was dismissed.

In fish which don't have the fast liver clearance issue seen in primates and rodents, resveratrol lengthened lifespan over 50 percent. The likely reason mice failed to show lifespan extension on resveratrol is due to fast liver clearance of resveratrol. But newer formulations promise to alleviate this issue somewhat and allow higher blood levels albeit temporarily.

If We Escape All Major Diseases, Neurodegeneration And Respiratory Failu...

Comment

Neurons were transplanted from mice to rats, and the mice neuron lived twice as long as the mice. The researchers believed that if transplanted into even longer lived animals they'd live even longer potentially indefinitely. Likely same for human. But the loss of respiratory reflex as cause of death in elderly was found in animals, and likely applies to humans too.

That is if vascular and support glia cells for neurons were kept youthful it is likely this would reduce rate of neuron death, and might allow for far longer neuron average lifespan potentially extending into two centuries or more.

That said it is true that for a real solution we do need central nervous system regeneration stem cells.

Telomere Biology: The Ultimate Biohack

Interestingly in this presentation, the degree of telomerase activation from the ingredients of telo vital one of the strongest telomerase activating supplements is discussed.   All animals that have indefinite lifespans have some mechanism to lengthen telomeres.

New upcoming resveratrol supplement

 Its called nugevia.

Appears to release in 2025

Uses a micellar technology for superior blood levels

Link to tech

https://jupiterneurosciences.com/jotrol/

Link to news on nugevia

https://www.nutraceuticalsworld.com/breaking-news/jupiter-neurosciences-launches-nugevia-supplement-line-for-longevity-and-performance/

This is very promising as way higher levels if only for limited time may enable some of the potential of resveratrol to shine through.

Resveratrol is the molecule with the strongest antiaging effects seen on cells.   Able to take old human cells and rejuvenate them to youthful state.   But the in vitro doses used are difficult to achieve or sustain in vivo due to fast clearance.

But newer formulations promise to unlock part of the potential of this molecule in vivo.

From another news article this appears to be the product website

https://nugevia.com/

RESVERATROL - The Truth Will SHOCK You! (only on this channel!)

The benefits of the promising longevity molecule resveratrol are discussed.  Resveratrol is very promising but part of its benefits are limited in humans due to its fast clearance through the liver.  Newer formulations appear might offer promise of increasing its benefits.

Key Food to Extend Your Lifespan by 5 Years

2 minute short video on food that may increase lifespan.  Oily fish is the food that can increase lifespan by 5 years.  Omega 3 in particular seem important.

Comment on aging regards Gene expression vs more radical changes as pertains lifespan increases.

At least at the cellular level, it seems altering gene expression makes old cells indistinguishable from young cells in the lab under a microscope.   If you go by what Bill Andrews and Michael Fossel comment, iirc.

Some of them(Fossel, iirc) seem to believe that if gene expression is changed, the body will clear the garbage out.    The inability to process garbage locally shouldn't be too concerning, as systems like the brain have the glymphatic system that routinely exports molecular garbage out(when it malfunctions you get neurodegeneration diseases, when not you get superagers with 20 year old brain function.).   It is likely, imho, in young animals the lymphatic system plays a similar role and exports molecular garbage out of tissues.   But with aging it is compromised, and along with increased garbage production, garbage starts  to accumulate.

In human society houses don't process all of their garbage, they merely export it out for disposal or recycling, wouldn't surprise if nature does similar.   Look at the brain for example, an extremely high metabolism organ, neurons have similar metabolic costs between species, yet we live 3 times as long as bonobos who share 98% of our genes.  Our common ancestor likely had similar short lifespan, but to increase the lifespan, even tripling it, even of organs like the brain, it was mostly gene expression changes that allowed it, not novel radical mechanisms.-link to source

Longevity can be predicted by number of cortical neurons in an animal or so it seems.
https://onlinelibrary.wiley.com/doi/full/10.1002/cne.24564

Crucially, the finding that no correlation between
maximal longevity and metabolic rate remains after accounting for
variation in numbers of cortical neurons argues strongly against
the common notion that damages accumulate at rates that scale
across species depending on metabolism (West et al., 1997).-Herculano Houzel (2018)

Interesting snippet as well as the following

While this new possibility has yet to be investigated, it
leads to one clear prediction: those species with the largest number
of cells in the relevant organ(s) will live longer before succumbing
to physiological breakdown and disintegration and,
consequently, death.-Herculano Houzel (2018)

And yet another related snippet from the news

"The data suggest that warm-blooded species accumulate damages at the same rate as they age. But what curtails life are damages to the cerebral cortex, not the rest of the body; the more cortical neurons you have, the longer you will still have enough to keep your body functional,” said Herculano-Houzel.-source 

But it seems to me that if this were the case you'd see massive lifespan reductions in indivduals with half a brain, which does occur in humans.   Otherwise this would seem to suggest aging may very well be programmed.

Paper on research on the evolution of aging, mortality

"..We created such a model to look at the evolution of intrinsic mortality, and were surprised to find the counterintuitive result that lifespan self-limitation is favored even in the absence of other conditions that could intuitively make it favorable – for instance, if animals had to stop reproducing at a certain age, or in a rapidly changing world where you needed new mutations always to be coming along to cope with the changing conditions, it would make sense to clear out old individuals and replace them with new ones." The study's key results show that even without such limiting conditions – that is, if an organism could live and keep reproducing indefinitely, and was just as adapted to the world as its offspring – the lineage would ultimately do better if genes encoded a mechanism that brings about death.

Read more at: http://phys.org/news/2015-07-death-spatial-natural-favors-genetically-limited.html#jCp

Thing is if there's an aging program, as some suspect, the possibility of radical life extension becomes more likelier, and it is believed probably would require less drastic interventions.