Sunday, October 27, 2019
Tuesday, October 22, 2019
Comment on aging regards Gene expression vs more radical changes as pertains lifespan increases.
At least at the cellular level, it seems altering gene expression makes old cells indistinguishable from young cells in the lab under a microscope. If you go by what Bill Andrews and Michael Fossel comment, iirc.
Some of them(Fossel, iirc) seem to believe that if gene expression is changed, the body will clear the garbage out. The inability to process garbage locally shouldn't be too concerning, as systems like the brain have the glymphatic system that routinely exports molecular garbage out(when it malfunctions you get neurodegeneration diseases, when not you get superagers with 20 year old brain function.). It is likely, imho, in young animals the lymphatic system plays a similar role and exports molecular garbage out of tissues. But with aging it is compromised, and along with increased garbage production, garbage starts to accumulate.
In human society houses don't process all of their garbage, they merely export it out for disposal or recycling, wouldn't surprise if nature does similar. Look at the brain for example, an extremely high metabolism organ, neurons have similar metabolic costs between species, yet we live 3 times as long as bonobos who share 98% of our genes. Our common ancestor likely had similar short lifespan, but to increase the lifespan, even tripling it, even of organs like the brain, it was mostly gene expression changes that allowed it, not novel radical mechanisms.-link to source
Some of them(Fossel, iirc) seem to believe that if gene expression is changed, the body will clear the garbage out. The inability to process garbage locally shouldn't be too concerning, as systems like the brain have the glymphatic system that routinely exports molecular garbage out(when it malfunctions you get neurodegeneration diseases, when not you get superagers with 20 year old brain function.). It is likely, imho, in young animals the lymphatic system plays a similar role and exports molecular garbage out of tissues. But with aging it is compromised, and along with increased garbage production, garbage starts to accumulate.
In human society houses don't process all of their garbage, they merely export it out for disposal or recycling, wouldn't surprise if nature does similar. Look at the brain for example, an extremely high metabolism organ, neurons have similar metabolic costs between species, yet we live 3 times as long as bonobos who share 98% of our genes. Our common ancestor likely had similar short lifespan, but to increase the lifespan, even tripling it, even of organs like the brain, it was mostly gene expression changes that allowed it, not novel radical mechanisms.-link to source
Interesting longevity finding regarding astaxanthin.
Interesting finding. The fact that astaxanthin increases lifespan in some species, and also appears to protect cell membranes, make it very promising.
An Astaxanthin compound has been found to switch on the FOX03 'Longevity Gene' in a study using mice. Researchers measured a nearly 90% increase in the activation of the gene in the animals' heart tissue. Life sciences company Cardax, Inc. looks forward to further confirmation in human clinical trials of Astanxanthin's potential role as an anti-aging therapy. -link
Wednesday, October 2, 2019
Wednesday, September 25, 2019
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