Wednesday, October 29, 2014

Excerpt from an old article on CR relating to humans

“Speaking of humans,” Fontana added, “if you are lean because you are exercising, of course you are doing good, because you’re preventing types of diabetes, some kinds of cardiovascular disease and maybe some types of cancers. But the data suggest that calorie restriction is more powerful. And the people on C.R. are more powerfully protected from diseases than the exercisers.”

Fontana connected his point to his continuing observations of some Calorie Restriction Society members. “In terms of cardiovascular diseases — the No. 1 cause of death; 4 out of 10 people die of it in the U.S. and Europe — we know that they will not die of cardiovascular death,” Fontana said. His subjects have cholesterol around 160, blood pressure around 100 over 60, high HDL, low triglycerides and very low levels of inflammation. “So these people won’t develop these diseases,” he said. “And I think that’s an important finding. Because every day doctors are publishing hundreds of papers on circulation research and medications that are lowering blood pressure or cholesterol by a small bit. And here we have such a powerful intervention that is basically cleaning out the arteries.” At Tufts, Susan Roberts, the lead investigator, echoed this position, saying that the study will probably have greater effects than the average clinical trial. “I don’t know why anyone would take drugs when they could do something like this,” Roberts said, referring to Calerie.-link

A nice article regarding CR in humans, this is only a small interesting bit.

On degrees of CR viable in longer lived animals

My next interview was so upsetting that it is difficult to write about, and it shows that CR can, in certain cases, lead to full-blown anorexia. I called Al at home; his voice was quiet and somewhat difficult to hear. I asked how many calories a day he ate (1,950, he said) and how much he weighed.
"Ninety-two," he answered. I hoped I'd heard wrong. "How tall are you?" I asked. "Five-four," he said. "But I used to be 5-feet-11." He paused. "Osteoporosis." His spine had compressed a full 7 inches—or perhaps he was bent over. I was glad we were on the phone and I couldn't see him.
Al, who is 59, said he began CR in 1989 after reading about it in a textbook co-written by CR guru Roy Walford. -link

It is likely that the CR performed here was more extreme and has now become more moderate.  Such examples suggest that extreme CR might not be recommendable for longer lived animals prone to bone loss over time.    
More moderate CR, combined with CR mimetics should be viable and not entail such side effects(adequate calcium intake and vitamin k2 should probably also be helpful).   Several CR mimetics are said to not be additive with maximal CR(around 65% restriction), but should likely have additive effect on more moderate CR.    An interesting compound that should hopefully be tested in mammals, is rhodiola, which is a compound that is additive with CR and even maximal CR in a species of insect.   The mechanisms of rhodiola are also of interest seeing as it can move some species' lifespan beyond maximal CR

nice global ilumination vid ue4

Monday, October 27, 2014

Nice quote on computational processes

A computational process is indeed much like a sorcerer's idea of a spirit. It cannot be seen or touched. It is not composed of matter at all. However, it is very real. It can perform intellectual work. It can answer questions. It can affect the world by disbursing money at a bank or by controlling a robot arm in a factory. The programs we use to conjure processes are like a sorcerer's spells. They are carefully composed from symbolic expressions in arcane and esoteric programming languages that prescribe the tasks we want our processes to perform.-link

 And the world is entering an age, were the most powerful of all such is about to come into existence, where the design of artificial minds become possible.  It is then that entities of immense capability can be summoned into this world.  

Monday, October 20, 2014

Nice quote on gene expression and calorie restriction

 "Aging was accompanied by changes in gene expression associated with increased inflammation, cellular stress, and fibrosis, and reduced capacity for apoptosis, xenobiotic metabolism, normal cell-cycling, and DNA replication. LT-CR and just 4 weeks of ST-CR reversed the majority of these changes."-link

Effects seen in liver of rodents, reversal of most age related changes in gene expression, if I'm not mistaken.
LTCR long term calorie restriction
STCR short term calorie restriction