Graph showing life extension in various species
extend the lifespan of yeast up to 70%
Treatment of flies in early adulthood with 100 μM resveratrol was shown to extend mean lifespan [16]. The same dose of resveratrol was demonstrated to increase mean worm lifespan also, without any changes in fecundity
https://www.sciencedirect.com/science/article/pii/S0925443915000216
Both aging accelerated as well as normal but shorter lived mice strains also experienced life extension
Beginning at two months of age, the mice were divided to receive a standard diet, or a diet supplemented with resveratrol. In SAMP8 mice fed a standard diet, the median life expectancy was 10.4 months in comparison with the SAMR1 group which survived a median of 17.8 months. However, in SAMP8 mice given resveratrol, median life expectancy increased to 14 months, and SAMR1 mice that received the compound experienced a median life span of 21.8 months. Maximum life span, determined by the longest-lived 20 percent of animals in each group, was also greater in animals that received resveratrol.
https://www.lifeextension.com/newsletter/2013/3/resveratrol-increases-life-span-in-mice
In the new study — which compared the genetic crosstalk of animals on a restricted diet with those fed small doses of resveratrol — the similarities were remarkable, explains lead author Jamie Barger of Madison-based LifeGen Technologies. In the heart, for example, there are at least 1,029 genes whose functions change with age, and the organ’s function is known to diminish with age. In animals on a restricted diet, 90 percent of those heart genes experienced altered gene expression profiles, while low doses of resveratrol thwarted age-related change in 92 percent. The new findings, say the study’s authors, were associated with prevention of the decline in heart function associated with aging.
https://news.wisc.edu/agent-in-red-wine-found-to-keep-hearts-young/
Despite lengthening the lifespan of most short lived species its been tried on, the reason resveratrol might not work as effectively in longer lived species could be due to the age related decline in NAD+ seen in longer lived species. This is because resveratrol is believed to work primarily through the activation of multiple sirtuins, and sirtuins use NAD+, a decline in NAD+ hinders their function and resveratrol's effectiveness.
It is likely nad+ boosters like NMN, NR, Nicotinic Acid, Apigenin, among others may counter the age related declines in NAD+ enough that resveratrol may continue to function.
In some studies in mice it was found resveratrol lengthened telomeres but did so more strongly in younger versus old animals. This again could be due to the age related decline in NAD+
reference for telomere lengthening effect of resveratrol https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7735524/
