Omega 3 dosis analysis

 

Comment on the video watch this before you take fish oil from youtube channel nutrition made simple:

The video covers dosing, risks, dangers, and benefits of omega 3s.  Also goes into fish oil and algae oil.

James Bond of Weight Loss: Once a Year Obesity Drug!

WVE-007 appears to provide an alternative to glp medicines for weight loss.  It mimics a naturally occurring mutation that appears mostly beneficial.  Suggesting that it might have low side effect risks, but of course testing is needed to see if that turns out to be true.

Walk This Way to Live Longer (Backed by New Science)

Even under 8k steps might still have notable benefits.  It is convenient to walk more than 15 minutes at a time to reduce all cause mortality.

Dr. Sinclair's Protocol Updates In 2025

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I take taurine, nmn, pqq, ergothioneine, urolithin a, spirulina, omega 3, magnesium, vitd+k2, hydroxytyrosol. Recently started taking nugevia resveratrol, which is best taken on a fasted empty stomach, iirc. Nugevia uses micellar resveratrol which is being tested as a resveratrol drug called Jotrol. 500mg Jotrol is said can exceed blood levels of 5g micronized resveratrol, nearly doubling them, that is it approaches levels that would take nearly 10g of expensive micronized resveratrol.

10g micronized is not just expensive but overloads system with metabolic byproducts, Jotrol can achieve the benefits of this at far lower dose without the side effects or issues of such high dose micronized.

In lemur primates, it was seen that high dose resveratrol was able to extend median lifespan over 20 percent, albeit too few primates were used to reach statistical significance in the study, and thus it was dismissed.

In fish which don't have the fast liver clearance issue seen in primates and rodents, resveratrol lengthened lifespan over 50 percent. The likely reason mice failed to show lifespan extension on resveratrol is due to fast liver clearance of resveratrol. But newer formulations promise to alleviate this issue somewhat and allow higher blood levels albeit temporarily.

If We Escape All Major Diseases, Neurodegeneration And Respiratory Failu...

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Neurons were transplanted from mice to rats, and the mice neuron lived twice as long as the mice. The researchers believed that if transplanted into even longer lived animals they'd live even longer potentially indefinitely. Likely same for human. But the loss of respiratory reflex as cause of death in elderly was found in animals, and likely applies to humans too.

That is if vascular and support glia cells for neurons were kept youthful it is likely this would reduce rate of neuron death, and might allow for far longer neuron average lifespan potentially extending into two centuries or more.

That said it is true that for a real solution we do need central nervous system regeneration stem cells.

Why ‘Healthy’ People Still Have Heart Attacks

Short video on how healthy people can experience heart attacks even with good bmis.   One of the potential causes is high visceral fat, which can be measured with waist circumference.

We'll Pay $101 Million If You Prove You Can Reverse Aging

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The exceptions to wear and tear, free radical oxidative stress theory of aging were explained by the membrane pacemaker theory of aging. And the exceptions to membrane pacemaker can be explained by presence of molecules such as plasmalogens that are not normally taken into account when calculating Peroxidation index. It is conceivable lowering membrane damage sufficiently would allow repair mechanisms to outclass rate of damage accumulation

NEW Japanese Walking Technique 2x Better Than 10,000 Steps

A method of interval walking where fast speed is intercalated with slow speed is mentioned.  While it has its benefits its not for everyone.  Some may prefer slow walking over long periods to any interval training using far more effort.

Rucking: Best Cardio for Longevity? (Science, Complete Guide, & 30 Day E...

Using weighted backpacks can help create resistance and improve the rate of weight loss.  But it is not for everyone.   Rucking, walking with weighted backpacks, has many benefits but again not for all.  Some people might have hurt backs and might not be able to handle it.

Better Than Cardio? How Weighted Vests Hack Your Fitness Biology | TUH #148

A video discussing weighted vests, and their potential benefits.  Again these are not for everyone.  But those that can handle it might see benefits, if done within reason or limits.

Is Calorie Restriction Overrated For Longevity? @Unaging.Crissman.Loomis

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The exceptions to rate of living theory were explained by membrane pacemaker theory.  Some have argued against it based on polyunsaturate composition of membranes but even here mitochondrial membrane differences and differences in other membrane molecules like plasmalogens explains these exceptions.

All in all reducing damage production explains between species differences in lifespan and also the way things like calorie restriction work.

Too severe CR is not good for humans at least Ive heard of some severe CR practitioners suffering significant bone loss.

I think 2 to 3 days of fasting mimicking diet combined with 4 to 5 days of high food based calcium intake with d3 k2 is probably good.   Food based sources like dairy, not artificial supplemental sources or fortified foods.  Artificial intake of calcium shows adverse outcomes in some studies, but not so natural food sources.

That said substances that improve mitochondrial function like urolithin a ergothioneine and pqq sound promising.  As is sources of plasmalogens or their precursors.

But with age membranes are changed such that their function worsens and they are more easily damaged.  Iirc these is due to changes in composition and the origin of these detrimental changes are unknown.  But Calorie Restriction opposes the body changing membranes in detrimental ways.  Also CR opposes many detrimental gene expression changes.  And it also has lots of good changes to parameters.

A brief comment on the membranes the membrane pacemaker theory of aging is based on membrane damage not being simple damage but the creation of autocatalytic reactive molecules able to cross both lipid and acqueous compartments damaging all parts of the cell including dna.

update:

While two long lived primate studies showed nebulous gains, another study on shorter lived primates showed massive lifespan gains from calorie restriction.  It was a lemur primate study.

Aubrey de Grey Reveals SECRET to Aging

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While I like membrane pacemaker damage theory of aging, there is issues such as neurons being able to live twice as long as animals they come from, and repeated cloning being possible both without signs of aging. There is also the claim telomere lengthening rejuvenates cell and tissue level phenotype from old to young. I suspect that the damage is causing some internal clock or clocks to move and age us. Given again single cells like neurons can live twice as long as the animal and some believe can live more than ten times as long without genetic change. If repeated cloning shows dividing cells can yield youthful tissue far beyond animal lifespan and same is true for nondividing cells the body seems able to handle damage fine bar some aging clock or program interfering.

This 64-Year-Old Grandma Was Beating Bryan Johnson

64 year old woman beat multimillionaire at longevity benchmarks with low cost approach.   This is highly promising for the average person knowing they can achieve similar results without having to resort to extraordinary measures.

RESVERATROL - The Truth Will SHOCK You! (only on this channel!)

The benefits of the promising longevity molecule resveratrol are discussed.  Resveratrol is very promising but part of its benefits are limited in humans due to its fast clearance through the liver.  Newer formulations appear might offer promise of increasing its benefits.

How Much Protein Powder Should I Take A Day?

The optimal protein amount for maximizing gains, muscle gains, while limiting costs is discussed.  Some have suggested massive amounts of protein are necessary, but the truth is that far less may actually be needed in the end.

Neuron Lifespan quotes and research

With neurons, nature developed biological immortality at the cellular level, but the animals needed to die to make way for the new generations, to allow for increased evolvability, or evolution rate, of the species.   Even in lowly rodents the neurons are capable of vastly outliving these short lived mammals.

“Neurons do not have a fixed lifespan,” says Magrassi. “They may survive forever. It’s the body that contains them that die. If you put them in a longer-living body, they survive as long as the new body allows them to. It increases our hope that extending lifespan will not necessarily result in brain depleted of neurons.”

https://www.nationalgeographic.com/science/article/neurons-could-outlive-the-bodies-that-contain-them

https://www.pnas.org/doi/10.1073/pnas.1217505110

telomere tech

A nice video regarding the promising science of telomerase inducers. The possibility of one day extending telomere length and possibly influencing health.