Wednesday, December 24, 2014

Resveratrol news 2014 december

For the new study, Sajish and Schimmel put TyrRS(tRNA synthetase called TyrRS) and resveratrol together and showed with tests including X-ray crystallography that resveratrol does indeed mimic tyrosine, well enough to fit tightly into TyrRS's tyrosine binding pocket. That binding to resveratrol, the team found, takes TyrRS away from its protein translation role and steers it to a function in the cell nucleus.
Tracking the resveratrol-bound TyrRS in the nucleus, the researchers determined that it grabs and activates the protein, PARP-1, a major stress response and DNA-repair factor thought to have a significance influence on lifespan. The scientists confirmed the interaction in mice injected with resveratrol. TyrRS's activation of PARP-1 led, in turn, to the activation of a host of protective genes including the tumor-suppressor gene p53 and the longevity genes FOXO3A and SIRT6.-machineslikeus link
 It seems that in addition to the previously known sirtuin 1 activity, resveratrol also activates other stress response mechanisms through TyrRS including SIRT6 and FOXO3A.    So resveratrol appears to be acting through more than one pathway and it also seems to activate some of these mechanisms at lower doses according to the linked article