RESVERATROL BENEFITS AND LIFESPAN EXTENSION

  Graph showing life extension in various species

extend the lifespan of yeast up to 70%

 Treatment of flies in early adulthood with 100 μM resveratrol was shown to extend mean lifespan [16]. The same dose of resveratrol was demonstrated to increase mean worm lifespan also, without any changes in fecundity

 https://www.sciencedirect.com/science/article/pii/S0925443915000216

Both aging accelerated as well as normal but shorter lived mice strains also experienced life extension

Beginning at two months of age, the mice were divided to receive a standard diet, or a diet supplemented with resveratrol. In SAMP8 mice fed a standard diet, the median life expectancy was 10.4 months in comparison with the SAMR1 group which survived a median of 17.8 months. However, in SAMP8 mice given resveratrol, median life expectancy increased to 14 months, and SAMR1 mice that received the compound experienced a median life span of 21.8 months. Maximum life span, determined by the longest-lived 20 percent of animals in each group, was also greater in animals that received resveratrol.

 https://www.lifeextension.com/newsletter/2013/3/resveratrol-increases-life-span-in-mice

In the new study — which compared the genetic crosstalk of animals on a restricted diet with those fed small doses of resveratrol — the similarities were remarkable, explains lead author Jamie Barger of Madison-based LifeGen Technologies. In the heart, for example, there are at least 1,029 genes whose functions change with age, and the organ’s function is known to diminish with age. In animals on a restricted diet, 90 percent of those heart genes experienced altered gene expression profiles, while low doses of resveratrol thwarted age-related change in 92 percent. The new findings, say the study’s authors, were associated with prevention of the decline in heart function associated with aging.

 https://news.wisc.edu/agent-in-red-wine-found-to-keep-hearts-young/

Despite lengthening the lifespan of most short lived species its been tried on, the reason resveratrol might not work as effectively in longer lived species could be due to the age related decline in NAD+ seen in longer lived species.  This is because resveratrol is believed to work primarily through the activation of multiple sirtuins, and sirtuins use NAD+, a decline in NAD+ hinders their function and resveratrol's effectiveness.

It is likely nad+ boosters like NMN, NR, Nicotinic Acid, Apigenin, among others may counter the age related declines in NAD+ enough that resveratrol may continue to function. 

In some studies in mice it was found resveratrol lengthened telomeres but did so more strongly in younger versus old animals.   This again could be due to the age related decline in NAD+

reference for telomere lengthening effect of resveratrol https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7735524/

Forever young at heart, the power of resveratrol

 Taking into account the beneficial effects of RES on hypertension, obesity, inflammation, diabetes and dyslipidemia, RES could constitute an interesting pharmacological approach for the treatment of metabolic syndrome, which is associated with an increased risk of CVD development. Nevertheless, among the points to discuss for the interpretation of preclinical and clinical studies, not only the poor bioavailability and the dose of RES are critical, but also the length of RES treatment and the best time for initiating it (most studies showed effectiveness of RES when it was administered for short periods and as a pretreatment) [67]. Larger controlled human clinical trials are thus needed to investigate these points and to study the effects of long-term RES supplementation. Resveratrol and Cardiovascular Diseases (nih.gov)

In mice resveratrol has lengthened lifespan of obese mice abolishing practically abolishing lifespan negative effects of obesity, it has also lengthened lifespan of aging accelerated mice, of mice with mitochondrial defects, of normal aging but short lived strains of mice, of yeast, of short lived fish, and of a few other species.

It is able to elicit antiaging effects in multiple organs but most strongly in the heart, where iirc, it induces hundreds of gene expression changes opposed to aging and akin to calorie restriction(calorie restriction being one of the strongest youth resilience and health promoting antiaging interventions known.), this has already been shown in animals

Resveratrol presents a therapeutic agent with a novel mechanism of action that appears to benefit a variety of conditions related to CVD and HF. Ongoing studies will test the hypothesis that the addition of resveratrol in meaningful doses can help patients with CVD and/or HF. The Effects of Resveratrol in Patients with Cardiovascular Disease and Heart Failure: A Narrative Review (nih.gov)

Animal gene expression research

 Surprisingly, resveratrol opposed 947 (92%) of age-related changes in gene expression, and 522 of these represented highly significant differences in expression between the old control and old resveratrol groups (P≤0.01). Thus, resveratrol at doses that can be readily achieved through dietary supplementation in humans is as effective as CR in opposing the majority of age-related transcriptional alterations in the aging heart. Because the collection of such alterations in gene expression is a biomarker of aging, our results imply that similar to CR, middle-age onset resveratrol supplementation at low doses is likely a robust intervention in the retardation of cardiac aging. A Low Dose of Dietary Resveratrol Partially Mimics Caloric Restriction and Retards Aging Parameters in Mice (nih.gov)