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I take taurine, nmn, pqq, ergothioneine, urolithin a, spirulina, omega 3, magnesium, vitd+k2, hydroxytyrosol. Recently started taking nugevia resveratrol, which is best taken on a fasted empty stomach, iirc. Nugevia uses micellar resveratrol which is being tested as a resveratrol drug called Jotrol. 500mg Jotrol is said can exceed blood levels of 5g micronized resveratrol, nearly doubling them, that is it approaches levels that would take nearly 10g of expensive micronized resveratrol.
10g micronized is not just expensive but overloads system with metabolic byproducts, Jotrol can achieve the benefits of this at far lower dose without the side effects or issues of such high dose micronized.
In lemur primates, it was seen that high dose resveratrol was able to extend median lifespan over 20 percent, albeit too few primates were used to reach statistical significance in the study, and thus it was dismissed.
In fish which don't have the fast liver clearance issue seen in primates and rodents, resveratrol lengthened lifespan over 50 percent. The likely reason mice failed to show lifespan extension on resveratrol is due to fast liver clearance of resveratrol. But newer formulations promise to alleviate this issue somewhat and allow higher blood levels albeit temporarily.
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