Tracing root goals

 Brief comment on the concept of tracing root goals.

Often the pursuit of a goal is actually set in truth with the intent or perhaps not a real intent but purpose of a deeper goal.

These deeper goals need not even align or be what the agent truly seeks personally.   For example the goal of attracting a mate, is deep down its purpose is reproduction or the perpetuation of the species or preservation of genetic information.  Yet a human may use contraceptives and even do so throughout their lives impeding reproduction whilst interacting with a mate.

If any goal is no better necessarily in principle, tracing root goal or the origin of purpose behind a goal and following root goal instead of downstream goal seems more reasonable and intelligent.

Take a man that does art to gain money to be able to start a family and to have children.   Focusing on producing art or producing money, is not as meaningful as creating the family and providing and protecting them.

Likewise natural selection through the evolution of life has produced ever greater richness and variety.  The goal of each species, of preservation and continuation of their line as well as the fundamental of survival of life itself seems like something at the root of the system.

Preserving not just the existing system but the evolution and growth of richness and complexity of information.  In humans information also continued to enrich through culture.

The birth of a perfect lifeform, a perfect race, adept at conquering the cosmos, the stars, adept at preserving and enriching the evolution of information, seems like something that is worthy of pursuit.  Entities able to fulfill the root goal of all life.

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Edit just noticed video must be seen in youtube.

Will give my 2 cents,

Just shows how cbdc and those in favor of it likely consider the masses as useless eaters to be treated like dogs on a leash or cattle that must be hearded before slaughter.

The cbdc full monitoring and control of all money assets and ability to restrict purchases as well as restrict access to funds and deperson a person by essentially not only having absolute control over their money but being able to cut all access to it.

Basically cbdc enables bank freeze like action on ones money without any court order.   It also enables rationing you can only buy so much butter, bread, toilet paper, or water.   You can only buy these types of cars or appliances.

If the government doesnt like your business they wont just be able to harass you with irs but also block consumers ability to buy from your business.

It is very disgusting.   And those supporting such control of the masses are disgusting. Recently an anticbdc bill passed.   Iirc most democrats seem to support cbdc aka dog leash like control over the masses.  Unless this bill had nasty pork hidden in, not supporting it is unacceptable.   Shows disdain and utter hatred for the voters.

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Comment

The exceptions to rate of living theory were explained by membrane pacemaker theory.  Some have argued against it based on polyunsaturate composition of membranes but even here mitochondrial membrane differences and differences in other membrane molecules like plasmalogens explains this exceptions.

All in all reducing damage production explains between species differences in lifespan and also the way things like calorie restriction work.

Too severe CR is not good for humans at least Ive heard of some severe CR practitioners suffering significant bone loss.

I think 2 to 3 days of fasting mimicking diet combined with 4 to 5 days of high food based calcium intake with d3 k2 is probably good.

That said substances that improve mitochondrial function like urolithin a ergothioneine and pqq sound promising.  As is sources of plasmalogens or their precursors.

But with age membranes are changed such that their function worsens and they are more easily damaged.  Iirc these is due to changes in composition and the origin of these detrimental changes are unknown.  But Calorie Restriction opposes the body changing membranes in detrimental ways.  Also CR opposes many detrimental gene expression changes.  And it also has lots of good changes to parameters.

A brief comment on the membranes the membrane pacemaker theory of aging is based on membrane damage not being simple damage but the creation of autocatalytic reactive molecules able to cross both lipid and acqueous compartments damaging all parts of the cell including dna.

A link to the paper covering details of membrane pacemaker theory of aging

 

More than 100 years ago, Max Rubner combined the fact that both metabolic rate and longevity of mammals varies with body size to calculate that "life energy potential" (lifetime energy turnover per kilogram) was relatively constant. This calculation linked longevity to aerobic metabolism which in turn led to the "rate-of-living" and ultimately the "oxidative stress" theories of aging. However, the link between metabolic rate and longevity is imperfect. Although unknown in Rubner's time, one aspect of body composition of mammals also varies with body size, namely the fatty acid composition of membranes. Fatty acids vary dramatically in their susceptibility to peroxidation and the products of lipid peroxidation are very powerful reactive molecules that damage other cellular molecules. The "membrane pacemaker" modification of the "oxidative stress" theory of aging proposes that fatty acid composition of membranes, via its influence on peroxidation of lipids, is an important determinant of lifespan (and a link between metabolism and longevity). The relationship between membrane fatty acid composition and longevity is discussed for (1) mammals of different body size, (2) birds of different body size, (3) mammals and birds that are exceptionally long-living for their size, (4) strains of mice that vary in longevity, (5) calorie-restriction extension of longevity in rodents, (6) differences in longevity between queen and worker honeybees, and (7) variation in longevity among humans. Most of these comparisons support an important role for membrane fatty acid composition in the determination of longevity. It is apparent that membrane composition is regulated for each species. Provided the diet is not deficient in polyunsaturated fat, it has minimal influence on a species' membrane fatty acid composition and likely also on it's maximum longevity. The exceptional longevity of Homo sapiens combined with the limited knowledge of the fatty acid composition of human tissues support the potential importance of mitochondrial membranes in determination of longevity.

https://www.researchgate.net/publication/51113341_Metabolism_and_longevity_Is_there_a_role_for_membrane_fatty_acids

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very nice discussion of an intriguing paper covering some of the limits of the current llms.