Start with the fly or C. Elegans, achieve very robust results, i.e. not a mere doubling of natural lifespan, then move up the ladder!
C. Elegans lifespan has been increased 10 fold, iirc.
Regards flies, I'm not sure how long lasting their exoskeleton and wings are. If it is not too long lasting it could be a determinant of lifespan, and lifespan increases merely a result of working around mechanical fatigue of nonregenerating elements.
3D printed organs - no closer
? Tissue engineered Bladders have been implanted in humans and been fully working for years. Vast improvements have supposedly occurred in 3d printing biotissues behind the scenes to enable thicker more complex tissue to be grown. Now that chimera research is about to go into overdrive, we will circumvent the whole problem, as a womb can provide full vasculature and all the intrinsic stem cell signals through embryoninc development, no need to know the exact details of the whole process to actually use it.
As I've said with our new more advanced genetic engineering capabilities we could put the DRASTIC metabolic slowdown under adverse conditions capabilities seen in some animals into human cells, expression of such genes could even be regulated by a drug of choice, this would allow the tissues to be built in 3d fashion and withstand longer periods without blood supply. This would require probably changes to the immune system of the new host to be compatible with these changes if it is not merely the result of gene expression changes but actual novel proteins. But it would be ACE for 3d printing biomachines, and biodroids.
Nad+- causes brain cancer
BOLLOCKS, at most it might promote already existing ones. And again this means ZERO, ZILCH, if you are one of the individuals blessed with advanced cancer immunity this will likely have no detriment.
Resverastrol - doesn't work
Resveratrol worked to extend obese mice lifespan to normal nonobese levels. IT also extended the lifespan of multiple shorter lived species including vertebrates. It triples human cell survival to gamma radiation exposure, iirc. But it depends on NAD to work and on longer lived species it seems NAD becomes age related depleted, but we've found ways around that, so resveratrol should work in theory if the NAD depletion is solved.
As for what to study to learn about aging. There are species where the individual members have EXACTLY THE SAME GENOME but the lifespan difference is over 10 fold, I think it's dozens of time longer in some members. A mere change in gene expression allows for dozens fold increase in lifespan. Clearly we could see what allowed for this. Heck even within a human some cells last quite little while others last over 120+ years(longer even than most humans.) showing again dozens fold lifespan difference between cells, yet same exact genome.-source link
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