Blade Runner is a 1982 American science fiction cyberpunk/tech-noir film directed by Ridley Scott, and starring Harrison Ford, Rutger Hauer, Sean Young, and Edward James Olmos. The screenplay, written by Hampton Fancher and David Peoples, is a modified film adaptation of the 1968 novel Do Androids Dream of Electric Sheep? by Philip K. Dick.
The film depicts a dystopian Los Angeles in which genetically engineered replicants, which are visually indistinguishable from adult humans, are manufactured by the powerful Tyrell Corporation. The use of replicants on Earth is banned and they are exclusively utilized for dangerous or menial work on off-world colonies. Replicants who defy the ban and return to Earth are hunted down and killed ("retired") by special police operatives known as "Blade Runners". The plot focuses on a group of recently escaped replicants hiding in L.A. and the burnt-out expert Blade Runner, Rick Deckard (Harrison Ford), who reluctantly agrees to take on one more assignment to hunt them down.-source wiki
People have talked about metal robots or robots with artificial polymer skins ,these may take place. But a form of advanced synthetic biology is going to be very hard to surpass, the only competing less realistic tech is what is called hard nano, whether hard nano can be used to make self-repairing, self-maintaining, ageless humanoids remain in question. The laws of physics, the true laws, do not forbid the creation of synthetic humans, humans born of intelligent design through computer assisted design software.
So it may come to pass, that one day, assuming the human world doesn't self destruct, progress will allow for artificial ageless humans of any race, gender or age. Humans who may be born with synthetic brains filled with knowledge of a thousand lifespans, more than a thousand years of experience from birth.