Wednesday, August 3, 2016

Immune cancer therapies on the horizon

"Immune cell therapy inducing complete remission in some cancer patients and improved t-cell therapy could work for most patients
...Now, versions of the therapy for a limited number of blood cancers are nearing approval by federal regulators, and could reach the market as early as next year.
The technique, known as cell therapy, gives each patient an individualized and souped-up version of their own immune system, one that “works better than nature made it,” as Dr. June puts it.... So far, the number of patients treated with cell therapy is in the hundreds, not thousands. And for now it works only for certain types of blood cancers, not common malignancies like breast and lung cancer. Researchers are also still working out how to control potentially lethal side effects."-source nextbigfuture

Cool new cancer therapies on the horizon.

And comment on the article:
There are centenarians who like to eat lots of meat, and like it burnt black, aka full of carcinogens.  They've been eating that all their life.  There are also lifelong two pack a day smoker centenarians, lots of carcinogens in the lung. Obviously after so many decades cancerous cells must have arisen in their bodies.  Yet they're centenarians, which means we can say they probably did develop cancerous cells but survived.  How?  The most likely explanation is an immune system able to fight cancer.

Already it has been seen in some mice that there is a sort of cancer immunity present, able to naturally fight off implants of aggressive cancer cells:

 "Spring 1999. “Professor Cui, this mouse didn’t get cancer. Should I get rid of him?” It was a standard experiment in Zheng Cui’s lab at Wake Forest University, North Carolina: Inject inbred mice with cancer cells, not to study cancer, but to produce antibodies for a lipid experiment. “There must have been a mistake,” said Cui, “Inject him again.” Two weeks later, still no cancer. “Try again with a higher dose!” Still no cancer. No cancer even at a million times the lethal dose. Cui decided to breed the mutant mouse."-source huffington post

  Research in some humans also showed similar immune cells more apt at fighting cancer, indicating that some form of cancer immunity might be present in some humans.

Two interesting snippets from the above huffington post article:
 1st
"Cui began to seek funding to test the transfusion theory. He already knew support wouldn’t come easily; blood transfusions are old technology and so can’t be patented. The pharmaceutical industry of course would take no interest. And as Cui found, clinical oncologists resist anything outside the usual treatments, even when they have nothing more to offer their patients."-source huffington post

Again this bad horrible lust for uncontrollable wealth from many in the industry is sad.   Anything that can't make loads of money tends to be ignored, the pathetic thing is that many of the people involved from pharmaceutical CEOs to oncologists are drowning in cash from their large salaries, yet it seems many want more and can ignore promising new therapies if it won't satistify the uncontrollable lust for money.   I mean if you're already wealthy, this quest for more, more, more, well it's like some sort of mental disease especially when it costs human lives by delaying promising treatments.

2nd
"The bad news: His wife was diagnosed with stage IV squamous cell carcinoma with massive metastases to all her major organs (lungs, liver, spleen and kidneys) and was given months to live. She had run out of conventional treatment options after partial surgery and chemotherapy. But he planned to take her to China for treatment at his other trial site in March 2013. Two months ago, good news and bad news again. Good news: we met with Cui and his wife. She looked terrific. To the astonishment of her doctors, her condition appears completely stable after 14 months, with no further treatment of any sort. She told us the transfusions gave her a high fever, but no other side effects."-source huffington post

Further reading of the huffington post article shows how promising therapies go unfunded while millions go into pathetic drugs that at most tend to offer only a few more months of life with many side effects.   Cancer is an evolving, an adapting, living disease, to fight such immune therapies seem far more promising.   Given that some people live through decades of high carcinogen consumption, as mentioned above, and again still live symptom, disease, free, obviously the bodies of some are able to handle it, to defeat it.

It's good to see that at least some of those involved in cancer research can get what seems like access to such promising research.

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