The thing is, that there appear to be quality control mechanisms that ensure dysfunctional mitochondria are eliminated.
“Thus, suggesting that mitochondrial dysfunction is a good enough reason for eliminating mitochondria and as Dr. Skulachev says, mitochondria follow the samurai’s law; “it’s better to die than to be wrong”.”-Mitoptosis, a Novel Mitochondrial Death Mechanism Leading Predominantly to Activation of Autophagy, 2012
We already have the sequences of animals(bowhead whale) that appear to live for multiple centuries, and that according to some do not even appear to age. As far as I know, I’ve not heard of evidence of mitosens like solutions having evolved to allow such extreme longevity. Even in mammals, afaik, humans do not have further mitochondria genes transferred to the nucleus compared to shorter lived species like bonobos or mice, the solution to extend lifespan proposed in mitosens, iirc.
For all we know the only reason mitochondria dysfunction might occur is either inheritance of sufficient mutation load from parents or age related downregulation of quality control mechanisms.-Darian S, link to source
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