Some thoughts

I personally expect great things from advanced synthetic biology. I expect a biological multicellular machine to be designed that can take in all biological and nonbiological waste and break it down into useful raw materials to be stored. I also expect it to be able to manufacture most anything locally, and have some form of brain interface as well as vast computational power. IT will have years or decades of energy stored underground in case of a catastrophe such as nuclear winter.

In any case I expect most transactions and most time will be spent in VR once perfected. If our technology is made-up of negligible senescence cellular machines, we won't need to give it manual maintenance so we can abandon the physical world.