Reply/Comment to blog post over at Josh Mitteldorf's blog

Michael Fossel seems to suggest that increasing telomerase activity might be very promising regards rejuvenating tissues.   His latest interview in singularity one on one, almost seemed to imply that such would remove age related senescent cells by restoring them to a more youthful function.

I'm interested in knowing how good is Alpha Lipoic Acid regards telomerase activation, it appears to be an indirect activator via  PGC-1α
http://www.cell.com/cell-reports/fulltext/S2211-1247(15)00825-6

How would it compare to something like TA-65 at human tested doses of 600mg, 1200mg, and 1800mg?

How many cell types would it affect?

As for those talking about mutations if we had rejuvenated cells, even 100 year olds with aged less functional repair pathways, have only accumulated a few hundred mutations.   A newborn has about 50 new mutations and turns out fine.   Given billions of cells a few hundred mutations per century*(which may be far less if the cellular tissue are rejuvenated and have youthful repair and maintenance), is nothing to worry about... especially if you have cancer immunity as some fraction of the population seems to have.

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