comment on aging video by youtuber siimland

 

comment 1: The exceptions to the oxidative stress theory of aging (basically the evolved rate of living or free radical theory of aging) were explained by the membrane pacemaker theory of aging, whose own exceptions as pertains aging rate can be explained by the presence of antioxidant mechanisms such as the presence of plasmalogen molecules that act as sacrificial antioxidants.

Damage to membranes creates an autocatalytic chain reaction of damaging molecules that can bypass both lipid and aquatic sections of the cell damaging all components throughout the cell.   Species with high metabolic rate and high lifespan, achieve this by altering membrane peroxidation index or otherwise altering membranes to make them more resistant to damage, particularly the mitochondrial membrane.

The neuron of mice when transplanted into rats' lives twice as long as mice do.  It is believed that if transplanted into even longer-lived animals it'd live just as long as the host.  Even in humans' neurons last over 110 years longer than the average lifespan, and again it too might live as long as a longer-lived host if transplanted into such.

So at the cellular level a near agelessness was achieved in neurons.  Despite sustaining extensive genetic damage throughout the lifespan most seem to keep on working fine.  The fact humans age despite having ageless cells, and even mice too, is due to planned obsolescence.  Evolution optimizes lifespan to maximize evolvability, the rate of evolution for a particular species.

What can be done? Well look at insects despite the workers sharing same genome as queen, the lifespan difference can be up to dozens of times, iirc up to 100-fold difference in lifespan has been seen with different gene expression patterns.  It may be that we can take the anti-aging mechanisms used by neurons, perhaps even a fraction of these, and express them throughout the body by altering gene expression to increase membrane resistance to damage.

comment 2: resveratrol failed due to fast liver clearance, in animals without fast liver clearance above 50% life extension is achieved, including in vertebrates.   At very high dose it achieved over 20% life extension in primates albeit the group was too small to reach statistical significance.  New formulations of resveratrol such as JOTROL shows good promise, and is now undergoing clinical trials for some conditions.

comment on youtuber Felix Harder's video: This Natural Supplement INSTANTLY Destroys Dental Plaque (-92% In Just 24h!)

 

He focuses on DIM, related to cruciferous vegetables, but I've also heard k2 and xylitol are good for oral health too.

Recent video from Thomas Delauer on baking soda rinse and its benefits

Comment: In this video Delauer mentions the use of baking soda in specific proportions for mouth rinses, not only does it appear to help with plaque and cavities, but it also does not destroy beneficial bacteria.   Some traditional mouth washes destroy all bacteria and have been found harmful for health due to killing beneficial bacteria in the mouth.
 

Comment on video A Tiny Dose of this Mineral leads to a Massive Alzheimer’s Disease Reversing Effect by physionics

 

Comment: In both animals and humans, it appears like lack of lithium might have been linked potentially to Alzheimer's.  While more research is needed, this suggests that lithium might be protective.   Microdose lithium, which is available from various trusted brands might be beneficial.   Of course, lot of fraud in the supplement industry, so it is necessary to check for tests from places such as consumer labs, or reputable other third-party testers to confirm the ingredient is actually in the product being bought.

Antiaging therapy against glycation damage

 

Molecule that enzymatically reverses glycation damage has been tested and been successful in the lab.  In the near future might become available after human testing.  The video mentions potential interventions that might reduce damage in the mean time while waiting for this to become available.

Omega 3 dosis analysis

 

Comment on the video watch this before you take fish oil from youtube channel nutrition made simple:

The video covers dosing, risks, dangers, and benefits of omega 3s.  Also goes into fish oil and algae oil.

Video on longevity and immortality

 

Comment

we don't need brain emulation; we only need central nervous system regeneration. The neurons of mice can live over twice as long as mice and are believed could live indefinitely in a new host. Same likely applies to humans, if the body didn't age most neurons could last for centuries, and they could be slowly replaced with regeneration. Backups could assist regeneration, and the brain tissue could be genetically extremophile hardened to withstand prolonged blood or oxygen deprivation so as to survive extreme accidents while awaiting regeneration of body.

LDL permanently lowered with a single shot

 Interesting therapy that might arrive soon.  A gene editing therapy that permanently reduces cholesterol production to safer levels.  Albeit iirc the company wants to be paid as long as you remain cured even though its just a single treatment.  Though eventually the patent will run out and the treatment will be single payment permanent solution.

Longevity supplement list video

 

Dr. Matt Ranks Longevity Supplements: The Winners and Total Scams

Comment

Resveratrol has shown strong rejuvenation effects directly in human cells in vitro turning old human cells into young cells, it has extended the lifespan of over half a dozen species, and even in primates it extended lifespan by over 20% albeit too few primates to reach statistical significance. Reason it failed in rodents, is due to fast liver clearance, in fish with slow clearance over 50% extension is seen. New formulations might address this issue.

My New Cholesterol Numbers Shocked Even My Doctor

Nutritional changed led to vastly improved cholesterol numbers.  This vegan lifestyle channel now focuses on longevity.  But it is still an evidence-based channel, upholding to the mainstream science discoveries regards nutrition that have taken us far in the science of what is optimal for a long healthy lifestyle.

James Bond of Weight Loss: Once a Year Obesity Drug!

WVE-007 appears to provide an alternative to glp medicines for weight loss.  It mimics a naturally occurring mutation that appears mostly beneficial.  Suggesting that it might have low side effect risks, but of course testing is needed to see if that turns out to be true.

Walk This Way to Live Longer (Backed by New Science)

Even under 8k steps might still have notable benefits.  It is convenient to walk more than 15 minutes at a time to reduce all cause mortality.

Why ‘Healthy’ People Still Have Heart Attacks

Short video on how healthy people can experience heart attacks even with good bmis.   One of the potential causes is high visceral fat, which can be measured with waist circumference.

"HGH Was Catastrophic" - The Exotic Drugs In Bryan Johnson's "Don't Die"...

Some of the drugs used by Millionaire longevity enthusiast Bryan Johnson are discussed.  As well as ones that didn't pan out.

Mercury Toxicity

Symptoms of mercury toxicity are mentioned.  There's a long list of symptoms.   Mercury is very bad for health.   Things to ameliorate it are mentioned.

The Most Common Cause of Liver Transplant

Talks of acetaminophen being the cause behind many liver transplants.  4 grams is an overdose, even 3 grams is the limit, and this might be dangerous depending on the condition of the liver.

At the 1st Sign of Dementia: Do This

The symptoms of dementia, at least some potential ones, are listed in this video.  As well as suggestions on what to do upon seeing or experiencing some of these first signs.

Longevity diets: fasting, signalling pathways, senolytics, microbiomes &...

Valter Longo and Sheekey discuss longevity in this episode.  Very good and informative knowledge regards healthy aging and fighting the diseases of aging.  

Joe Rogan Experience #1349 - David Sinclair

In this podcast famous longevity researcher Doctor David Sinclair is brought.  Sinclair is the researcher who popularized resveratrol and nmn.  He is now working on gene therapies that may reverse aging. He also came up with the information theory of aging.

Doctor Reviews Meatless Burgers | Impossible, Beyond & More!

The burgers not trying to imitate meat can be healthy, but so far most that have tried to imitate meat have been unhealthy, or as unhealthy as regular meat burgers if not more.