Tuesday, September 7, 2021
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Thursday, August 12, 2021
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Tuesday, August 10, 2021
Monday, August 9, 2021
Friday, August 6, 2021
Copyright: Forever Less One Day
Thursday, August 5, 2021
Wednesday, August 4, 2021
Chris Chan Gets Way Worse... Will Be Housed With Females
Forever young at heart, the power of resveratrol
Taking into account the beneficial effects of RES on hypertension, obesity, inflammation, diabetes and dyslipidemia, RES could constitute an interesting pharmacological approach for the treatment of metabolic syndrome, which is associated with an increased risk of CVD development. Nevertheless, among the points to discuss for the interpretation of preclinical and clinical studies, not only the poor bioavailability and the dose of RES are critical, but also the length of RES treatment and the best time for initiating it (most studies showed effectiveness of RES when it was administered for short periods and as a pretreatment) [67]. Larger controlled human clinical trials are thus needed to investigate these points and to study the effects of long-term RES supplementation. Resveratrol and Cardiovascular Diseases (nih.gov)
In mice resveratrol has lengthened lifespan of obese mice abolishing practically abolishing lifespan negative effects of obesity, it has also lengthened lifespan of aging accelerated mice, of mice with mitochondrial defects, of normal aging but short lived strains of mice, of yeast, of short lived fish, and of a few other species.
It is able to elicit antiaging effects in multiple organs but most strongly in the heart, where iirc, it induces hundreds of gene expression changes opposed to aging and akin to calorie restriction(calorie restriction being one of the strongest youth resilience and health promoting antiaging interventions known.), this has already been shown in animals
Resveratrol presents a therapeutic agent with a novel mechanism of action that appears to benefit a variety of conditions related to CVD and HF. Ongoing studies will test the hypothesis that the addition of resveratrol in meaningful doses can help patients with CVD and/or HF. The Effects of Resveratrol in Patients with Cardiovascular Disease and Heart Failure: A Narrative Review (nih.gov)
Animal gene expression research
Surprisingly, resveratrol opposed 947 (92%) of age-related changes in gene expression, and 522 of these represented highly significant differences in expression between the old control and old resveratrol groups (P≤0.01). Thus, resveratrol at doses that can be readily achieved through dietary supplementation in humans is as effective as CR in opposing the majority of age-related transcriptional alterations in the aging heart. Because the collection of such alterations in gene expression is a biomarker of aging, our results imply that similar to CR, middle-age onset resveratrol supplementation at low doses is likely a robust intervention in the retardation of cardiac aging. A Low Dose of Dietary Resveratrol Partially Mimics Caloric Restriction and Retards Aging Parameters in Mice (nih.gov)
Tuesday, August 3, 2021
Comment on time crystal thread on reddit regards perpetual motion and limits of science or technological power
the fact the patent office dismisses perpetual motion machines is not really a good claim that they are impossible. For starters the government is known to take technology out of the patent office remove it from patents database and issue NDA by threat of force to anyone with any world revolutionizing patented tech.(that said doubt they have perp motion)
Also I remember my physics teacher saying how negative refraction was impossible, iirc. Yet metamaterials made it possible.
Einstein's relativity works precisely because Newton's laws break in certain extreme cases. The laws of thermodynamics need not hold in all cases.
Also people commenting on quantum physics have said that not only can universes appear from nothing given quantum laws but so too can brains spontaneously appear out of the vacuum and so too can golden apples.
A solid gold apple could suddenly appear out of thin air in front of you and fall to the ground, just extremely low probability. So could an entire harem of naked ladies, but it too is of such extremely low probability it wouldn't happen in like a googleplex years.
But digital physics suggests there is no true randomness only pseudorandomness exists, the dice of the universe are loaded or fixed. And through sufficient technology we may be able to alter probability of events, which would result in reality control science or reality warping. This is the ultimate power, the science of information holds in a world made up of information, the power of a god of information. Such may be the power of the final theory of physics, or it may fall short of that.
The stories of men say anything is impossible through science, united man can conquer the heavens, the power of god is in man's hands with the knowledge of the tree of knowledge.
https://www.reddit.com/r/singularity/comments/ouz667/eternal_change_for_no_energy_a_time_crystal/
Monday, August 2, 2021
Friday, July 30, 2021
Lectures: Exploring the Psychology of Creativity
Thursday, July 29, 2021
Wednesday, July 28, 2021
Comment on religious thread over at neogaf.
That the meaning of a system can't be contained wiithin the system, is debatable, as fractals a fraction can contain the whole, as well as holograms, and I believe thus is the nature of god too.
As for mind not being knowable from brain, that is only for the time being, we are starting to know mind from brain with recent experiments.
The mind will be explainable naturalistically.
The idea of something from nothing, life from nonlife, etc, is seen when rules even simple ones come about, from simple rules everything can emerge.
As for information conservation, that is correct information is neither created nor destroyed, as was at the beginning will be at the end.
The information from the beginning merely evolves from beginning to end. The word is merely expressed through the passage of time.
All is computable, including the human mind. Computation cannot create or destroy information, as he says it can merely transform it change it, and the law of change is evolution, grasp this law and you grasp the nature of life.
He comments on if his wife was a robot, not knowing the true levels of machine capability, he imagines clunky past machines, but his wife is a natural robot, a series of molecular machines with support molecules and the molecular tape providing the instructions. There is a button press like logic behind human interactions and human relations, it is that simple at bottom. It is reflected in the biblical stories, and the logic is shared by all known stories I've been exposed. In fact it is present in all of human writings.
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All paths converge on truth.
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Newton doubted Descartes clockwork like universe, but gravity is computed by a digital computer following rules, an immaterial clockwork, wherein Descartes believed it material clock it is immaterial clock, rule following system.
The philosopher stone is also immaterial in nature, and it can indeed cure any ailment and grant immortality, the philosopher stone is another way to say truth. The idea that truth can hold a finite body, is contested by some, but affirmed by others.
edit to further elaborate, everything is composed of symbols and symbols have meaning. Every action, every expression, every word or letter, even every error is but a signal, signals carry meaning or intent, even intent beyond that which the person has.
That is how you can begin to grasp the button press like nature of human interaction and fables such as the sword of damocles, or the fire sword of eden. Symbols are akin to buttons, they are pressed one way or the other and even not pressing or sending a symbol is also an action or a button press. Inaction is also another type of action.
Friday, July 23, 2021
Thursday, July 22, 2021
Neural darwinism, snippet
Neural Darwinism is a biological, and more specifically Darwinian and selectionist, approach to understanding global brain function, originally proposed by American biologist, researcher and Nobel-Prize recipient[1] Gerald Maurice Edelman (July 1, 1929 – May 17, 2014). Edelman's 1987 book Neural Darwinism[2] introduced the public to the Theory of Neuronal Group Selection (TNGS) – which is the core theory underlying Edelman's explanation of global brain function.
Owing to the book title, TNGS is most commonly referred to as the Theory of Neural Darwinism, although TNGS has roots going back to Edelman and Mountcastle's 1978 book, The Mindful Brain – Cortical Organization and the Group-selective Theory of Higher Brain Function – where Edelman's colleague, the American neurophysiologist and anatomist Vernon B. Mountcastle (July 15, 1918 – January 11, 2015), describes the columnar structure of the cortical groups within the neocortex,-wiki
https://en.wikipedia.org/wiki/Neural_Darwinism