Showing posts with label supercentenarian. Show all posts
Showing posts with label supercentenarian. Show all posts

Monday, February 3, 2014

chocolate...


It is rare for men to make it to centenarian rarer still to supercentenarian(110+), here we see that one of the foods consumed was chocolate. Which reminds of Jeanne Calment who also consumed chocolate. UPDATE: Some sources claim it is possible the age may be off by 10 years which would give 100+ rather than 110+, still impressive but not as impressive.

Friday, January 31, 2014

Century breakthroughs comment

The 3 most important breakthroughs that can happen, AI, VR, Immortality are likely to take place this century. I'm confident the human survival curve can be squared by lifestyle, nutraceuticals and drugs. We will know what works and what doesn't in the coming decades but if the curve is squared that would mean most can reach 100-110 that's ignoring more radical breakthroughs.

For example it may be possible to analyze telomeres, dna, and genome wide gene expression on a large group and check on them in 5 to 10 years determining mortality over that period and increases, decreases, etc. Some centenarians can eat red meat like abaddon, others smoke dozens of cigarettes a day for decades others don't exercise often yet some remain independent dementia free surgery free cancer free. That's 100+years. Exercise gives about 5 years(and helps square survival too), but if we knew the expression pattern of such centenarians and used drugs, lifestyle or nutrients to replicate it we could very well obtain 20+ years over the average lifespan... that's happening in the coming decades, so I think adding 20~years over average lifespan is safe bet(which should buy plenty of time for radical breakthroughs in case they arrive somewhat later than expected).

UPDATE:

Regards immortality, our ability to analyze and modify genes, will allow us to perfect the naturally occurring phenomena of negligible senescence.   It will be applied to our bodies through organ and cellular transplants, cells and organs massively genetically modified, our immune systems will also be modified to be compatible with any novel protein produced by these new tissues.    This is the power of advanced synthetic biology, applied to the design and operation of human cells, tissues, and organs.  The creation of super cells, tissues and organs.   Muscles and bones for example could be designed to synthesize and utilize novel molecular structures such as carbon nanotubes in novel ways, greatly enhancing strength, and potentially speed.

As for AI, true AI, it will allow for full automation, and the ability to accelerate the rate of progress beyond anything that's ever been seen.  If digital physics is true, then eventually the perfection of the science of mind design, will allow for the summoning of  the 'true' individuals from any time period or location real or fictional, past, present, or future.   Effectively, it will be like teleportation or time travel of minds, such that minds distant in time or space can be brought near.   And if all is digital, this will be the exact truly the same individuals, a true version of them instantiated.   

VR, or advanced VR-AR(virtual reality - augmented reality), will occur with the advent of advanced brain computer interfaces.  This will allow for any sensation to be experienced at any time, and the perfect recall of any experience or sensation, including those which could be shared by others from their personal lives(say how a traumatic experience felt, vividly and perhaps indistinguishably from one having lived it, so as to relate more).    This will allow for collective shared mass multisensory 'hallucination', in essence the brain will become partially divorced from the physical world and will become subject to the mental world manifesting in ways indistinguishable from physical reality.   Man's art, dreams, will permeate experience, and it will be collectively shared.

Tuesday, January 28, 2014

Calorie Restriction study comments

Regards humans in history. Humans present a very large population far larger than that of any study in CR. The greater number of centenarians in some populations has been attributed to moderate CR.

It is also likely that some humans may exhibit mutations conferring the benefits of CR, we would have to look at the gene expression of centenarians and supercentenarians to see if it is similar or not to that caused by CR. If the gene expression profiles are similar, even if only in some, it would be probable evidence for CR working in humans.

Also from what I've heard CR can work in some species of rodents all the way down to 50% and is rumored could work down at even lower levels if not for death by starvation. IF this is true a CR-mimetic could in theory break the 50% limit when it comes to changes in gene expression and might allow for even longer lifespan..

As for these two studies it would be interesting to see what the weights of the primates were compared to wild animals. It may be that in both cases the CR was too moderate, and both the CR and control fell within normal or slightly less than normal consumption levels for these animals.-fightaging
Also I should add regards the primate studies it would be interesting to note protein intake, and whether there was protein supplementation in the feed as it appears some primates require reduced protein intake for some of the effects of CR(IGF-1 levels)-link
 IT has to be seen what the normal levels of protein are for the animal in the wild, even if the calorie reduction also reduced protein, it may still have resulted in higher than normal protein intake for this type of animal.

It would also have to be seen the type of protein fed,  some types are said to raise IGF-1 which may mean that even the reduced IGF-1 might not have matched or gone below wild type.

Comment regarding negative result on primate studies, and human history potential for CR being implemented and effective as well as possible genetics mimicking CR.

Snippet on JeanneCalment's lifestyle

Calment smoked from the age of 21 (1896) to 117 (1992), though according to an unspecified source, she smoked no more than two cigarettes per day.

Calment ascribed her longevity and relatively youthful appearance for her age to olive oil, which she said she poured on all her food and rubbed onto her skin, as well as a diet of port wine, and ate nearly one kilogram (2.2 lb) of chocolate every week. Calment reportedly remained mentally intact until her very end.-link
A nice snippet. Regarding some factoids of the lifestyle of the longest living human yet, as of this posting.2.2lb is about 10 100g chocolate bars per week!