Sunday, June 22, 2025

IS AGING PROGRAMMED? Aubrey de Grey vs. Yuri Deigin debate at Vitalist B...


comment: one thing is that parasites, diseases, germline mutations accumulate with age, fighting all of these is easiest by killing organism, that is in addition to increased evolvability. Also, the exceptions to the free radical theory of aging were explained away with the membrane pacemaker theory of aging, wherein membrane resilience determines rate of damage accumulation. Evolution determines membrane composition, during Calorie Restriction and similar interventions organism even alters membrane composition in a controlled manner increasing lifespan drastically.

In organisms like insects same genome different epigenetic regulation allows 10x--100x lifespan difference between queen and workers. But even here, it was believed queens of some species might be immortal, but for whatever reason it was found that sequential replacement with clones was easier for nature than actual immortality, the longest lasting queens last like 30 years ageless iirc, with extreme reproduction.

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