Saturday, November 22, 2014

A response to a post in josh mitteldorf's site

 "but only 15% to dogs and 5% or less in Rhesus monkey experiments reported last year. "

The 16% on dogs, was on 25% CR, iirc not maximal 65% CR.   Human igff1 levels have been influenced by protein intake, which may also affect other long lived species igf1 which may affect longevity

As for the primate study the earlier findings of small benefits were questioned this year.   It seems that not only have several monkeys who started CR in adulthood exceeded the maximum lifespan in captivity of the species studied, but those not on CR experienced triple the risk of death

Regards resveratrol, it has not only extended the life of fish, worms, yeast, obese mice, but also mitochondrially dysfunctional mice and several types of senescent accelerated mice strains.   It also tripled human cell survival upon exposure to gamma radiation.    Why it failed on normal mice, is a good question....  the fact that their nad goes drastically down with age, iirc, could be a culprit as this might handicap sirtuin activity which necesitates it, iirc, even in the presence of sirtuin activity enhancing compounds such as resveratrol. -Darian S, link to post in blog

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