"Aging was accompanied by changes in gene expression associated with increased inflammation, cellular stress, and fibrosis, and reduced capacity for apoptosis, xenobiotic metabolism, normal cell-cycling, and DNA replication. LT-CR and just 4 weeks of ST-CR reversed the majority of these changes."-link
Effects seen in liver of rodents, reversal of most age related changes in gene expression, if I'm not mistaken.
LTCR long term calorie restriction
STCR short term calorie restriction