Sunday, June 1, 2014

Sirtuins revisited

We now know that metazoans have multiple nutrient-sensing pathways
that can affect the life span (e.g., insulin signaling)
(Kenyon 2010), TOR (Johnson et al. 2013), AMP kinase
(Kahn et al. 2005), and sirtuins (Guarente 2000). Any
variability in laboratory conditions might favor signaling
through different subsets of these pathways, explaining
the reported differences in the genetic requirements
for CR in lower organisms (Speakman and Mitchell
2011).SIRT1 activators-link

An article overview of sirtuins and their connection to calorie restriction.

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